Affiliations 

  • 1 Department of Pharmaceutical Chemistry, Pannai College of Pharmacy, Dindigul - 624005, India (Affiliated to The Tamil Nadu Dr. M.G.R. Medical University, Tamil Nadu, Chennai, India
  • 2 Department of Molecular and Cell Biology, Greensmed Labs, Chennai, 600097, Tamil Nadu, India
  • 3 Department of Pharmaceutical Chemistry, Srinivasan College of Pharmaceutical Sciences, Samayapuram, Trichy, 621 112, India
  • 4 Department of Pharmacognosy, C.L. Baid Metha College of Pharmacy, Chennai, 600096, India
  • 5 Centre for Research and Innovation, University of Cyberjaya, Persiaran Bestari, Cyber 11, 63000, Cyberjaya, Selangor, Malaysia. drashokbalaraman@gmail.com
  • 6 Department of Molecular and Cell Biology, Greensmed Labs, Chennai, 600097, Tamil Nadu, India. greensmedlabs@gmail.com
PMID: 39560753 DOI: 10.1007/s00210-024-03547-0

Abstract

The primary purpose of this review is to explore the green synthesis of silver nanoparticle (AgNP) using natural biomolecules derived from marine sources. This review aims to evaluate the effectiveness of environmentally friendly approaches for synthesizing AgNPs and to examine their potential applications across various fields such as medicine, biotechnology, and environmental remediation. The key research question focuses on understanding how marine biomolecules, including polysaccharides, proteins, enzymes, amino acids, alkaloids, and vitamins, contribute to the formation of AgNPs and how these green-synthesized nanoparticles retain their functional properties. This review systematically examines current literature on the green synthesis of AgNPs, focusing on marine-derived biomolecules such as polysaccharides, proteins, and alkaloids. The methodology includes analyzing green synthesis techniques and comparing them with traditional chemical methods to highlight environmental benefits and overall efficiency. Various marine species, such as seagrass and seaweed, are explored as potent agents in the reduction of silver ions. The findings reveal that green synthesis of AgNPs using marine biomolecules is not only environmentally sustainable but also retains the desirable properties of the nanoparticles, such as antimicrobial, antioxidant, and anticancer activities. Additionally, the green-synthesized AgNPs show significant potential applications in mosquito control, wound healing, and anticancer therapies. Green synthesis of AgNPs using marine sources presents a viable and sustainable alternative to conventional chemical methods, significantly reducing the environmental impact of nanoparticle production while ensuring biocompatibility and functional integrity. This approach holds promise for diverse applications in biomedicine, environmental remediation, and beyond. Further research is recommended to address challenges in scaling up production and commercialization.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.