Malformations vs. Neoplasia in the Oral Cavity: Special Emphasis on Mixed Odontogenic Tumors

Soluk-Tekkesin M 1 , Bologna-Molina R 2 , Magliocca K 3 , van Heerden W 4 , Robinson L 4 , Bilodeau EA 5 Show all authors , Hussaini HM 6 , Adisa AO 7 , Tilakaratne WM 8 , Li J 9 , Hunter KD 10 , Gomez RS 11

Affiliations 

  • 1 Department of Oral Pathology, Faculty of Dentistry, University of Istanbul, Istanbul, Türkiye
  • 2 Diagnostic in Oral Pathology and Oral Medicine Department, School of Dentistry, Universidad de la Republica (UDELAR), Montevideo, Uruguay
  • 3 Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, USA
  • 4 Department of Oral and Maxillofacial Pathology, School of Dentistry, University of Pretoria, Pretoria, South Africa
  • 5 Oral and Maxillofacial Pathology, UDHS Oral Pathology Laboratory, University of Pittsburgh School of Dental Medicine, Pittsburgh, Pennsylvania, USA
  • 6 School of Dentistry, University of Otago, Dunedin, New Zealand
  • 7 Department of Oral Pathology, Faculty of Dentistry, College of Medicine, University of Ibadan, Ibadan, Nigeria
  • 8 Department of Oral and Maxillofacial Clinical Sciences, Faculty of Dentistry, Universiti Malaya, Kuala Lumpur, Malaysia
  • 9 Department of Oral Pathology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
  • 10 Liverpool Head and Neck Centre, Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, UK
  • 11 Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
J Oral Pathol Med, 2024 Dec 01.
PMID: 39617625 DOI: 10.1111/jop.13592

Abstract

BACKGROUND: The terminology surrounding developmental lesions in the oral cavity is widely applied, often leading to confusion in differentiating between developmental malformations and neoplasia. Odontogenic tumor classification includes both true neoplasms and malformations which make it very complex and dynamic.

METHOD AND CONCLUSION: In this brief report, we will first discuss the concepts of malformations and neoplasia and then focusing on their relevance to odontogenic tumors, which impacts their classification and treatment, particularly mixed odontogenic lesions.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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