A New Methylbutyric Acid Derivative with Pro-angiogenesis Activity from the Mangrove Fungus Penicillium polonicum M-3

Zhang Y 1 , Cao W 2 , Liu X 2 , Ma Z 2 , Li P 3 , Chen H 4 Show all authors , Fan Y 5

Affiliations 

  • 1 Qingdao Agricultural University, School of life, 700# Changcheng Road, Qingdao, China, Qingdao, CHINA
  • 2 Qingdao Agriculture University: Qingdao Agricultural University, School of life, 700# Changcheng Road, Qingdao, China, Qingdao, CHINA
  • 3 Qilu University of Technology, Qilu University of Technology (Shandong Academy of Sciences), #3501 Daxue Road, Changqing District, Jinan, CHINA
  • 4 First Institute of Oceanography Ministry of Natural Resources, MNR Key Laboratory of Marine Eco-Environmental Science and Technology, 6# Xianxialing Road, Qingdao, China, Qingdao, CHINA
  • 5 Qingdao Agricultural University, School of sciences, 700# Changcheng Road, Qingdao, China, 266109, Qingdao, CHINA
Chem Biodivers, 2024 Dec 05.
PMID: 39638771 DOI: 10.1002/cbdv.202402399

Abstract

A new methylbutyric acid derivative penianoic acid A (1), along with fifteen known compounds (2-16), was isolated and identified from the culture extract of Penicillium polonicum M-3 sourced from Malaysian mangrove root soil. Their structures were determined by detailed spectroscopic analysis of NMR and MS data and quantum chemical calculations of ECD and NMR (with DP4+ probability analysis). The isolated compounds were evaluated for pro-angiogenesis activity using zebrafish in vivo model. Compounds 1, 3, 4, 6-10, and 12-15 showed potent in pro-angiogenic activity in transgenic zebrafish.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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