The limelight of adipose-derived stem cells in the landscape of neural tissue engineering for peripheral nerve injury

QingNing S 1 , Mohd Ismail ZI 2 , Ab Patar MNA 3 , Mat Lazim N 4 , Hadie SNH 5 , Mohd Noor NF 6

Affiliations 

  • 1 Department of Anatomy, School of Medical Sciences, Universiti Sains Malaysia Health Campus, Kubang Kerian, Kelantan 16150, Malaysia; Department of Rehabilitation, School of Special Education, Zhengzhou Normal University, Zhengzhou 450044, China. Electronic address: sunqingning77@student.usm.my
  • 2 Department of Anatomy, School of Medical Sciences, Universiti Sains Malaysia Health Campus, Kubang Kerian, Kelantan 16150, Malaysia. Electronic address: zulizhar@usm.my
  • 3 Department of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia Health Campus, Kubang Kerian, Kelantan 16150, Malaysia. Electronic address: azimpatar@usm.my
  • 4 Department of Otorhinolaryngology-Head & Neck Surgery, School of Medical Sciences, Universiti Sains Malaysia Health Campus, Kubang Kerian, Kelantan 16150, Malaysia. Electronic address: norhafiza@usm.my
  • 5 Department of Anatomy, School of Medical Sciences, Universiti Sains Malaysia Health Campus, Kubang Kerian, Kelantan 16150, Malaysia. Electronic address: snurma@usm.my
  • 6 Faculty of Medicine, Universiti Sultan Zainal Abidin Medical Campus, Kuala Terengganu, Terengganu 20400, Malaysia. Electronic address: faridmnoor@unisza.edu.my
Tissue Cell, 2024 Dec;91:102556.
PMID: 39293138 DOI: 10.1016/j.tice.2024.102556

Abstract

Challenges in treating peripheral nerve injury include prolonged repair time and insufficient functional recovery. Stem cell therapy coupled with neural tissue engineering has been shown to induce nerve regeneration following peripheral nerve injury. Among these stem cells, adipose-derived stem cells (ADSCs) are preferred due to their accessibility, expansion, multidirectional differentiation, and production of essential nutrient factors for nerve growth. In recent years, ADSC-laden nerve guide conduit has been utilized to enhance the therapeutic effects of tissue-engineered nerve grafts. This review explores existing research that recognizes the roles played by ADSCs in inducing peripheral nerve regeneration following injury and summarizes the different methods of application of ADSC-laden nerve conduit in neural tissue engineering.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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