Affiliations 

  • 1 Institute of Climate Adaptation and Marine Biotechnology, Universiti Malaysia Terengganu, Kuala Nerus, Terengganu, 21030, Malaysia
  • 2 Ocular Infections and Antimicrobials Research Group, Singapore Eye Research Institute, The Academia, 20 College Road, Discovery Tower, Singapore, 169856, Singapore
  • 3 Center for Nanotechnology and Sustainability, National University of Singapore, Singapore, 119260, Singapore
Macromol Rapid Commun, 2025 Feb 20.
PMID: 39973618 DOI: 10.1002/marc.202400903

Abstract

There is intense research during the past few decades to design and fabricate drug delivery systems using the electrospinning system. Electrospinning is an efficient technique to produce nanofiber materials with different dimensions and morphologies by adjusting the processing parameters. Electrospinning is becoming an innovative technology that promotes the pursuit and maintenance of human health. Herein, the review discusses the contribution of electrospinning technology in drug delivery systems, summarising the modification of the various electrospinning system configurations and the effects of the process parameters on fibers, their application in drug delivery including carrier materials, loaded drugs and their release mechanisms and illustrates their various medical applications. Finally, this review discusses the challenges, bottlenecks, and development prospects of electrospinning technology in the field of drug delivery in terms of scaling up for clinical use and exploring potential solutions to pave the way to establish electrospinning for future drug delivery systems.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.