Suppression of 8-oxoguanine DNA glycosylase (OGG1) activity produced positive impacts on disease severity, survival, and histopathological features of mice infected with Plasmodium berghei

Lawal MG 1 , Samaila A 2 , Basir R 3 , Abd Aziz NAL 4 , Alarabei AA 5 , Abdullah MA 6 Show all authors , Majid RA 7 , Nordin N 8 , Hussain MK 9 , Ismail EN 10

Affiliations 

  • 1 Department of Human Anatomy, Pharmacology Unit, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor Darul Ehsan, Malaysia; Department of Microbiology, Faculty of Natural & Applied Sciences, Umaru Musa Yar'adua University, P.M.B. 2218, Katsina State, Nigeria. Electronic address: mukhtar.gambo@umyu.edu.ng
  • 2 Department of Human Anatomy, Pharmacology Unit, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor Darul Ehsan, Malaysia; Department of Pharmacology, College of Health Sciences, Umaru Musa Yar'adua University, P.M.B. 2218, Katsina State, Nigeria. Electronic address: abdullahi.samaila@umyu.edu.ng
  • 3 Department of Human Anatomy, Pharmacology Unit, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor Darul Ehsan, Malaysia. Electronic address: rusliza@upm.edu.my
  • 4 Department of Human Anatomy, Pharmacology Unit, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor Darul Ehsan, Malaysia. Electronic address: aimiliyana.aziz98@gmail.com
  • 5 Department of Human Anatomy, Pharmacology Unit, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor Darul Ehsan, Malaysia. Electronic address: abdu.arabei@gmail.com
  • 6 Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia. Electronic address: maizaton@upm.edu.my
  • 7 Department of Pre-clinical, Faculty of Medicine and Defence Health, National Defence University of Malaysia, Kuala Lumpur, 57000, Malaysia. Electronic address: roslaini@upnm.edu.my
  • 8 Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia. Electronic address: shariza@upm.edu.my
  • 9 Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia. Electronic address: khairi@upm.edu.my
  • 10 Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia. Electronic address: elysha@upm.edu.my
Exp Parasitol, 2025 Mar 13;272:108930.
PMID: 40088963 DOI: 10.1016/j.exppara.2025.108930

Abstract

Malaria is a life-threatening disease, leading to significant morbidity and mortality. Malaria treatment remains a challenge due to its intricate pathophysiology and high levels of parasite resistance to many currently available antimalarial agents. Thus, there is an urgent need for more therapeutic strategies to combat the disease. OGG1 activity has been implicated in many inflammatory disease conditions, making suppressing OGG1 activity a potential target for therapeutic purposes. The current study aimed to determine the effect of suppressing OGG1 activity on the severity, survival, and histopathological features of P. berghei-infected mice. In this study, the effects of modulating OGG1 activity on parasitaemia development, disease progression, survival rate, and histopathological outcomes in major organs of Plasmodium berghei (P. berghei) infected mice were evaluated. A significant difference in the mean parasitaemia was observed between the Vehicle, TH5487-treated, and O8-treated mice (p 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

Similar publications