Primary Prevention of Cardiovascular Disease in Asia: Opportunities and Solutions: A Narrative Review

Dalakoti M 1 , Lin NHY 2 , Yap J 3 , Cader A 4 , Dipanker P 5 , Lee D 6 Show all authors , Raja Shariff RE 7 , Cuenza L 8 , Honda S 9 , Malis V 10 , Jiang H 11 , Hirachan A 12 , Chimura M 13 , Yeo TJ 2 , Yeo KK 3 , Jack Wei Chieh T 14 , Tromp J 15 , Loh PH 2 , Chew NWS 16 , Wong S 2 , Sia CH 16 , Tan BYQ 17 , Johar S 18 , Lip GYH 19 , Yang E 20 , Virani SS 21 , Hageman S 22 , Liu H 23 , Di Angelantonio E 24 , Dorairaj P 25 , Koh AS 26 , Chin C 26 , Al Mahmeed W 27 , Chan MY 16 , Foo R 16

Affiliations 

  • 1 Department of Cardiology, National University Heart Centre, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Singapore; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom. Electronic address: mayank_dalakoti@nuhs.edu.sg
  • 2 Department of Cardiology, National University Heart Centre, Singapore
  • 3 Department of Cardiology, National Heart Centre Singapore, Singapore; Duke-NUS Medical School, Singapore
  • 4 Department of Cardiology, Ibrahim Cardiac Hospital and Research Institute, Dhaka, Bangladesh
  • 5 Department of Cardiology, Shahid Gangalal National Heart Centre, Kathmandu, Nepal
  • 6 Department of Cardiology, Queen Elizabeth Hospital, Hong Kong
  • 7 Department of Cardiology, Universiti Teknologi MARA, Selangor, Malaysia
  • 8 Department of Cardiology, Philippines Heart Centre, Quezon City, Philippines
  • 9 Department of Cardiology, National Cerebral and Cardiovascular Centre, Suita, Osaka, Japan
  • 10 Department of Cardiology, Intercare Medical Centre, Phnom Penh, Cambodia
  • 11 Lee Kong Chian School of Medicine, Singapore
  • 12 Department of Cardiology, Mediciti Hospital Lalitpur, Lalitpur, Nepal
  • 13 Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
  • 14 Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Duke-NUS Medical School, Singapore
  • 15 Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Saw Swee Hock School of Public Health & the National University Health System, National University of Singapore, Singapore
  • 16 Department of Cardiology, National University Heart Centre, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Singapore
  • 17 Yong Loo Lin School of Medicine, National University of Singapore, Singapore
  • 18 Department of Cardiology, Raja Isteri Pengiran Anak Saleha Hospital, Bandar Seri Begawan, Brunei
  • 19 Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John. Moores University and Liverpool Heart and Chest Hospital, Liverpool, United Kingdom; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
  • 20 Division of Cardiology, University of Washington School of Medicine, Seattle, Washington, USA
  • 21 Department of Medicine, The Aga Khan University, Karachi, Pakistan; Section of Cardiovascular Research, Baylor College of Medicine, Houston, Texas, USA
  • 22 University Medical Center Utrecht, Utrecht, Netherlands
  • 23 The George Institute for Global Health, Sydney, Australia
  • 24 British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
  • 25 Center for Chronic Disease Control India, Delhi, India
  • 26 Department of Cardiology, National Heart Centre Singapore, Singapore
  • 27 Heart and Vascular Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, UAE
JACC Adv, 2025 Mar 21;4(4):101676.
PMID: 40120215 DOI: 10.1016/j.jacadv.2025.101676

Abstract

IMPORTANCE: Asia faces a rapidly rising burden of cardiovascular disease (CVD). Preventive cardiology efforts may help address the CVD epidemic.

OBSERVATIONS: Solutions to address the CVD burden include a cardiovascular risk assessment framework, improving health screening efforts, better cardiovascular risk factor management, novel innovation strategies encompassing targeted lifestyle measures, and strengthening governmental efforts. With the region's wide socioeconomic and other disparities, contextualizing and practical adaptation of various strategies into local practices, especially in low-middle-income countries, will determine the success of CVD prevention efforts.

CONCLUSIONS: A differential approach addressing cardiovascular risk factor screening, prevention, and management that considers the context-specific socioeconomic, governmental, and cultural aspects in diverse Asian populations may help reduce the rapidly rising CVD trajectory in Asia.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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