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Sequence comparison of six human microRNAs genes between tuberculosis patients and healthy individuals

Amila A 1 , Acosta A 2 , Sarmiento ME 1 , Suraiya S 3 , Zafarina Z 1 , Panneerchelvam S 1 Show all authors , Norazmi MN 4

Affiliations 

  • 1 School of Health Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia
  • 2 Institute for Research in Molecular Medicine Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia
  • 3 School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia
  • 4 School of Health Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia; Institute for Research in Molecular Medicine Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia. Electronic address: norazmimn@usm.my
Int J Mycobacteriol, 2015 Dec;4(4):341-6.
PMID: 26964819 DOI: 10.1016/j.ijmyco.2015.06.009

Abstract

MicroRNAs (miRNAs) play an important role in diseases development. Therefore, human miRNAs may be able to inhibit the survival of Mycobacterium tuberculosis (Mtb) in the human host by targeting critical genes of the pathogen. Mutations within miRNAs can alter their target selection, thereby preventing them from inhibiting Mtb genes, thus increasing host susceptibility to the disease.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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