Affiliations 

  • 1 Tan Soek-Siam, BA, MB BCH BAO, MRCP. Department of Hepatology, Selayang Hospital, Lebuhraya Selayang-Kepong, 68100 Batu Caves, Selangor, Malaysia. tansoeksiam@yahoo.com
  • 2 S Abdul Latif, MBBS. Department of Hepatology, Selayang Hospital, Lebuhraya Selayang-Kepong, 68100 Batu Caves, Selangor, Malaysia.
  • 3 Poh W Y, MPharm (Hons). Department of Pharmacy, Selayang Hospital, Lebuhraya Selayang-Kepong, 68100 Batu Caves, Selangor, Malaysia.
Med J Malaysia, 2012 Jun;67(3):323-5.
PMID: 23082426 MyJurnal

Abstract

Penicillamine toxicity in Wilson's disease has been well reported but rarely seen now as newer agents are being used. We present a case who developed multiple rare complications of Penicillamine concurrently. Our patient is one of three siblings on Penicillamine, she was the only one who developed massive breast enlargement four months after commencing Penicillamine therapy, as well as dermatological adverse reactions and myasthenia gravis three more months later. All the adverse effects improved soon after substitution of the offending agent with Trientine.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.