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Hepatoprotective action of various partitions of methanol extract of Bauhinia purpurea leaves against paracetamol-induced liver toxicity: involvement of the antioxidant mechanisms

Zakaria ZA 1 , Yahya F 2 , Mamat SS 2 , Mahmood ND 2 , Mohtarrudin N 3 , Taher M 4 Show all authors , Hamid SS 5 , Teh LK 6 , Salleh MZ 6

Affiliations 

  • 1 Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia. dr_zaz@yahoo.com
  • 2 Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia
  • 3 Department of Pathology, Faculty of Medicine & Health Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia
  • 4 Department of Pharmaceutical Technology, Kulliyyah of Pharmacy, International Islamic University Malaysia, Jalan Istana, Bandar Indera Mahkota, 25200, Kuantan, Pahang, Malaysia
  • 5 Medical Technology Division, Malaysian Nuclear Agency, Bangi, 43000, Kajang, Selangor, Malaysia
  • 6 Pharmacogenomics Centre (PROMISE), Faculty of Pharmacy, Universiti TeknologiMARA, 42300, Puncak Alam, Selangor, Malaysia
BMC Complement Altern Med, 2016;16(1):175.
PMID: 27287196 DOI: 10.1186/s12906-016-1110-4

Abstract

Methanol extract of Bauhinia purpurea L. (family Fabaceae) (MEBP) possesses high antioxidant and anti-inflammatory activities and recently reported to exert hepatoprotection against paracetamol (PCM)-induced liver injury in rats. In an attempt to identify the hepatoprotective bioactive compounds in MEBP, the extract was prepared in different partitions and subjected to the PCM-induced liver injury model in rats.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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