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Dysregulation of Glucose Homeostasis Following Chronic Exogenous Administration of Leptin in Healthy Sprague-Dawley Rats

Wjidan K 1 , Ibrahim E 2 , Caszo B 3 , Gnanou J 3 , Singh H 4

Affiliations 

  • 1 Master's Student, Faculty of Medicine, Universiti Teknologi MARA , Sungai Buloh, Malaysia
  • 2 Lecturer, Faculty of Medicine, Universiti Teknologi MARA , Sungai Buloh, Malaysia
  • 3 Associate Professor, Faculty of Medicine and Defence Health, National Defence University of Malaysia , Kem Sungai Besi, Kuala Lumpur, Malaysia
  • 4 Professor, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh, Malaysia; I-PerFFORM, Universiti Teknologi MARA , Selayang Campus, Selayang, Kuala Lumpur, Malaysia
J Clin Diagn Res, 2015 Dec;9(12):OF06-9.
PMID: 26816939 DOI: 10.7860/JCDR/2015/15594.7003

Abstract

Impaired glucose utilization is seen in chronic hyperleptinaemia associated conditions such as obesity and type 2 diabetes mellitus. It is unclear if this impaired glucose utilization is due to the effect of persistent hyperleptinaemia on insulin secretion from the beta cells of pancreas.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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