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Contributions of tropodithietic acid and biofilm formation to the probiotic activity of Phaeobacter inhibens

Zhao W 1 , Dao C 2 , Karim M 3 , Gomez-Chiarri M 4 , Rowley D 5 , Nelson DR 6

Affiliations 

  • 1 Department of Cell and Molecular Biology, University of Rhode Island, 120 Flagg Rd., Kingston, RI, 02881, USA. wenjing_zhao@hms.harvard.edu
  • 2 Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, RI, 02881, USA. Christine.Dao@umassd.edu
  • 3 Fisheries, Animal and Veterinary Sciences, University of Rhode Island, Kingston, RI, 02881, USA. murnimarlina@upm.edu.my
  • 4 Fisheries, Animal and Veterinary Sciences, University of Rhode Island, Kingston, RI, 02881, USA. gomezchi@uri.edu
  • 5 Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, RI, 02881, USA. drowley@uri.edu
  • 6 Department of Cell and Molecular Biology, University of Rhode Island, 120 Flagg Rd., Kingston, RI, 02881, USA. dnelson@uri.edu
BMC Microbiol, 2016 Jan 05;16:1.
PMID: 26728027 DOI: 10.1186/s12866-015-0617-z

Abstract

The probiotic bacterium Phaeobacter inhibens strain S4Sm, isolated from the inner shell surface of a healthy oyster, secretes the antibiotic tropodithietic acid (TDA), is an excellent biofilm former, and increases oyster larvae survival when challenged with bacterial pathogens. In this study, we investigated the specific roles of TDA secretion and biofilm formation in the probiotic activity of S4Sm.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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