Peripheral loss of CD8(+) CD161(++) TCRVα7·2(+) mucosal-associated invariant T cells in chronic hepatitis C virus-infected patients

Barathan M 1 , Mohamed R 2 , Vadivelu J 1 , Chang LY 1 , Saeidi A 1 , Yong YK 2 Show all authors , Ravishankar Ram M 1 , Gopal K 3 , Velu V 4 , Larsson M 5 , Shankar EM 1

Affiliations 

  • 1 Tropical Infectious Disease Research and Education Center (TIDREC), Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
  • 2 Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia
  • 3 Department of Orthopaedic Surgery, Tissue Engineering Group (TEG), NOCERAL, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
  • 4 Department of Microbiology and Immunology, Emory Vaccine Center, Atlanta, GA, USA
  • 5 Division of Molecular Virology, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden
Eur J Clin Invest, 2016 Feb;46(2):170-80.
PMID: 26681320 DOI: 10.1111/eci.12581

Abstract

Mucosal-associated invariant T (MAIT) cells play an important role in innate host defence. MAIT cells appear to undergo exhaustion and are functionally weakened in chronic viral infections. However, their role in chronic hepatitis C virus (HCV) infection remains unclear.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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