Increased frequency of late-senescent T cells lacking CD127 in chronic hepatitis C disease

Barathan M 1 , Mohamed R , Saeidi A , Vadivelu J , Chang LY , Gopal K Show all authors , Ram MR , Ansari AW , Kamarulzaman A , Velu V , Larsson M , Shankar EM

Affiliations 

  • 1 Department of Medical Microbiology, Tropical Infectious Disease Research and Education Center (TIDREC), University of Malaya, Lembah Pantai, Kuala Lumpur, Malaysia
Eur J Clin Invest, 2015 May;45(5):466-74.
PMID: 25721991 DOI: 10.1111/eci.12429

Abstract

Hepatitis C virus (HCV) causes persistent disease in ~85% of infected individuals, where the viral replication appears to be tightly controlled by HCV-specific CD8+ T cells. Accumulation of senescent T cells during infection results in considerable loss of functional HCV-specific immune responses.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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