Investigation of physical properties and stability of indomethacin-cimetidine and naproxen-cimetidine co-amorphous systems prepared by quench cooling, coprecipitation and ball milling

Lim AW 1 , Löbmann K 2 , Grohganz H 2 , Rades T 2 , Chieng N 1

Affiliations 

  • 1 School of Pharmacy, International Medical University, Bukit Jalil, Kuala Lumpur, Malaysia
  • 2 Department of Pharmacy, University of Copenhagen, København, Denmark
J Pharm Pharmacol, 2016 Jan;68(1):36-45.
PMID: 26663364 DOI: 10.1111/jphp.12494

Abstract

The objective was to characterize the structural behaviour of indomethacin-cimetidine and naproxen-cimetidine co-amorphous systems (1 : 1 molar ratio) prepared by quench cooling, co-evaporation and ball milling.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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