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Forkhead Box Transcription Factor (FOXO3a) mediates the cytotoxic effect of vernodalin in vitro and inhibits the breast tumor growth in vivo

Ananda Sadagopan SK 1 , Mohebali N 2 , Looi CY 3 , Hasanpourghadi M 4 , Pandurangan AK 5 , Arya A 6 Show all authors , Karimian H 7 , Mustafa MR 8

Affiliations 

  • 1 Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, 50603, Malaysia. asureshphd@gmail.com
  • 2 Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, 50603, Malaysia. nooshin.moheb86@gmail.com
  • 3 Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, 50603, Malaysia. looicy@um.edu.my
  • 4 Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, 50603, Malaysia. mohadeseh_hasanpour@yahoo.com
  • 5 Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, 50603, Malaysia. panduashokkumar@gmail.com
  • 6 Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur, 50603, Malaysia. aditya@um.edu.my
  • 7 Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur, 50603, Malaysia. Hamedkarimian61@gmail.com
  • 8 Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, 50603, Malaysia. rais@um.edu.my
J Exp Clin Cancer Res, 2015;34:147.
PMID: 26643256 DOI: 10.1186/s13046-015-0266-y

Abstract

Natural compounds have been demonstrated to lower breast cancer risk and sensitize tumor cells to anticancer therapies. Recently, we demonstrated that vernodalin (the active constituent of the medicinal herb Centratherum anthelminticum seeds) induces apoptosis in breast cancer cell-lines. The aim of this work was to gain an insight into the underlying anticancer mechanism of vernodalin using in vitro and in vivo model.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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