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Prevalence of the rs7903146C>T polymorphism in TCF7L2 gene for prediction of type 2 diabetes risk among Iranians of different ethnicities

Allahdini M 1 , Kamalidehghan B 2 , Akbari L 3 , Azadfar P 3 , Rahmani A 1 , Ahmadipour F 2 Show all authors , Meng GY 4 , Masserrat A 5 , Houshmand M 6

Affiliations 

  • 1 Department of Molecular Biology, Ahar Branch Islamic Azad University, Ahar, Iran
  • 2 Pharmacy Department, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
  • 3 Department of Biology, Sciences and Research Branch, Azad University, Tehran, Iran
  • 4 Department of Veterinary Preclinical Sciences, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Serdang, Malaysia
  • 5 Department of Medical Genetics, Taban Clinic, Tehran, Iran
  • 6 Department of Medical Genetics, National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran
Drug Des Devel Ther, 2015;9:5835-41.
PMID: 26604685 DOI: 10.2147/DDDT.S82485

Abstract

Pharmacogenetics is the study of genetic polymorphisms affecting responses to drug therapy. The common rs7903146 (C>T) polymorphism of the TCF7L2 gene has recently been associated with type 2 diabetes (T2D). In this study, prevalence of the rs7903146 (C>T) polymorphism in the TCF7L2 gene for prediction of T2D risk was examined in an Iranian population of different ethnicities.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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