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Oral consumption of α-linolenic acid increases serum BDNF levels in healthy adult humans

Hadjighassem M 1 , Kamalidehghan B 2 , Shekarriz N 3 , Baseerat A 4 , Molavi N 5 , Mehrpour M 6 Show all authors , Joghataei MT 7 , Tondar M 8 , Ahmadipour F 9 , Meng GY 10

Affiliations 

  • 1 Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran. mhadjighassem@tums.ac.ir
  • 2 Department of Pharmacy, Faculty of Medicine, University of Malaya (UM), Kuala Lumpur, Malaysia. kamalidehghan.behnam@gmail.com
  • 3 Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran. Nima.Shekarriz@gmail.com
  • 4 Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran. agv.bassirat@gmail.com
  • 5 Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran. mahditondar.bio@gmail.com
  • 6 Department of Neurology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran. mehrpr@yahoo.com
  • 7 Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran. Joghataei@yahoo.com
  • 8 Department of Biochemistry and Molecular & Cellular Biology, Georgetown University, Washington, USA. mt969@georgetown.edu
  • 9 Department of Pharmacy, Faculty of Medicine, University of Malaya (UM), Kuala Lumpur, Malaysia. ahmadipourf@gmail.com
  • 10 Department of Animal Science, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Serdang, Malaysia. b_kamali92@yahoo.com
Nutr J, 2015;14:20.
PMID: 25889793 DOI: 10.1186/s12937-015-0012-5

Abstract

Dietary omega-6 and omega-3 fatty acids have remarkable impacts on the levels of DHA in the brain and retina. Low levels of DHA in plasma and blood hamper visual and neural development in children and cause dementia and cognitive decline in adults. The level of brain-derived neurotrophic factors (BDNF) changes with dietary omega-3 fatty acid intake. BDNF is known for its effects on promoting neurogenesis and neuronal survival.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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