Systematic review and meta-analyses of vitamin E (alpha-tocopherol) supplementation and blood lipid parameters in patients with diabetes mellitus

Mohammad A 1 , Falahi E 2 , Barakatun-Nisak MY 3 , Hanipah ZN 4 , Redzwan SM 5 , Yusof LM 6 Show all authors , Gheitasvand M 7 , Rezaie F 8

Affiliations 

  • 1 Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, University Putra Malaysia, 43400, Serdang, Selangor, Malaysia. Electronic address: abolfathi.m54@gmail.com
  • 2 Nutritional Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran. Electronic address: e_falahi@yahoo.com
  • 3 Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, University Putra Malaysia, 43400, Serdang, Selangor, Malaysia; Research Centre of Excellence for NCD (Nutrition and Non-communicable Diseases), Universiti Putra Malaysia, UPM, 43400, Serdang, Selangor, Malaysia. Electronic address: bnisak@upm.edu.my
  • 4 Department of Surgery, Faculty of Medicine and Health Sciences, University Putra Malaysia, 43400, Serdang, Selangor, Malaysia. Electronic address: n_baidah@upm.edu.my
  • 5 Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, University Putra Malaysia, 43400, Serdang, Selangor, Malaysia. Electronic address: mohdredzwan@upm.edu.my
  • 6 Department of Companion Animal Medicine and Surgery, Faculty of Veterinary Medicine, Universiti Putra Malaysia, UPM, 43400, Serdang, Selangor, Malaysia. Electronic address: myloqman@gmail.com
  • 7 Department of Pathology, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran. Electronic address: Dr.gheitasvand@yahoo.com
  • 8 Department of Pathology, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran. Electronic address: f.rezaiee80@gmail.com
Diabetes Metab Syndr, 2021 05 31;15(4):102158.
PMID: 34186370 DOI: 10.1016/j.dsx.2021.05.031

Abstract

BACKGROUND AND AIMS: The studies have shown that α-tocopherol supplementation could improve lipid profile in diabetes mellitus (DM) patients. Nonetheless, the result remains inconsistent. Therefore, this meta-analysis was performed to evaluate the efficacy of α-tocopherol supplement on lipid parameters in DM patients.

METHODS: We conducted an extensive search via Cochrane Library, PubMed, Scopus, and Web of Science databases to acquire the reported RCTs up to October 2020.

RESULTS: The results showed no effects of α-tocopherol supplementation on lipid profile in DM patients except when used ≥12 weeks.

CONCLUSIONS: α-tocopherol supplementation in DM patients had no significant effect on lipid profiles.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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