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The Opposing Roles of IVS2+691 CC Genotype and AC/AG Diplotype of 118A>G and IVS2+691G>C of OPRM1 Polymorphisms in Cold Pain Tolerance Among Opioid-Dependent Malay Males on Methadone Therapy

Zahari Z 1 , Lee CS 2 , Ibrahim MA 2 , Musa N 2 , Yasin MA 2 , Lee YY 3 Show all authors , Tan SC 2 , Mohamad N 2 , Ismail R 2

Affiliations 

  • 1 Department of Pharmacy, Hospital Universiti Sains Malaysia, Kota Bharu, Kelantan, Malaysia. zzalina@usm.my
  • 2 Pharmacogenetics and Novel Therapeutics Cluster, Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia (USM), Kota Bharu, Kelantan, Malaysia
  • 3 School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Kelantan, Malaysia
Pain Ther, 2015 Dec;4(2):179-96.
PMID: 26581429 DOI: 10.1007/s40122-015-0041-y

Abstract

We recently reported that a majority of opioid-dependent Malay males on methadone therapy are cold pain sensitive. It is postulated that common OPRM1 polymorphisms may be responsible. This study investigated the association between 118A>G (dbSNP rs1799971) and IVS2+691G>C (dbSNP rs2075572) variants on cold pain responses among opioid-dependent Malay males on methadone maintenance therapy.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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