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Transient hyperthyroidism following L-asparaginase therapy for acute lymphoblastic leukemia

Fadilah SAW 1 , Faridah I 2 , Cheong SK 3

Affiliations 

  • 1 S A W Fadilah, MMed. Department of Haematology and Transplantation, MAKNA-HUKM Cancer Institute, Hospital Universiti Kebangsaan Malaysia, Jalan Tenteram, Cheras, 56000 Kuala Lumpur
  • 2 I Faridah, MMed. Department of Medicine (Division of Endocrinology), Hospital Universiti Kebangsaan Malaysia, Jalan Tenteram, Cheras, 56000 Kuala Lumpur
  • 3 S K Cheong, FRCP. Department of Haematology and Transplantation, MAKNA-HUKM Cancer Institute, Hospital Universiti Kebangsaan Malaysia, Jalan Tenteram, Cheras, 56000 Kuala Lumpur
Med J Malaysia, 2000 Dec;55(4):513-5.
PMID: 11221167

Abstract

The effect of L-asparaginase on the thyroid gland has not been well documented. We report the first two cases of hyperthyroidism associated with thyroid nodule following L-asparaginase therapy for acute lymphoblastic leukemia (ALL). The thyroid function abnormalities were not severe, short-lived and did not require specific therapy.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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