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COX-2 inhibitors: a potential target for drug therapy in the management of colorectal cancer

Ryan ARA 1 , Rosita ARA 1 , Kamarul AK 2 , Qureshi A 2

Affiliations 

  • 1 Department of Biochemistry, Royal College of Surgeons in Ireland, Dublin, Ireland
  • 2 Department of Surgery, Hospital Ultliversiti Kebangsaan. Malaysia, Jalan Tenteram, Cheras, Kuala Lumpur
Med J Malaysia, 1999 Sep;54(3):293-5.
PMID: 11045053

Abstract

Colorectal cancer is currently the third most common cancer in Malaysia. Elevated expression of COX-2, an induced cyclooxygenase isoenzyme, has been seen in colonic adenomas and colorectal carcinoma. There is evidence that inhibition of this COX-2 can decrease the risk of colorectal cancer. Selective COX-2 inhibitors may have a role in reducing the risk of colorectal cancer in high-risk individuals.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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