Association between microRNA-196A2 and microRNA-146A polymorphisms and progression to cirrhosis and hepatocellular carcinoma in patients with viral hepatitis B

Riazalhosseini B 1 , Mohamed Z , Apalasamy YD , Eng HS , Mohamed R

Affiliations 

  • 1 aThe Pharmacogenomics Laboratory, Department of Pharmacology bDepartment of Medicine cDepartment of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
Pharmacogenet Genomics, 2016 Feb;26(2):74-9.
PMID: 26529280 DOI: 10.1097/FPC.0000000000000187

Abstract

MicroRNAs (miRNAs) are small noncoding RNAs that have been implicated in mechanisms underlying various types of cancers including hepatocellular carcinoma (HCC). Reports have indicated that single nucleotide polymorphisms in miRNA-196A2 and miRNA-146A genes may contribute to the risk of progression of hepatitis B virus (HBV) infection to cirrhosis and HCC. This study aimed to examine the effect of miRNA-196A2 and miRNA-146A polymorphisms on the progression of HBV infection to cirrhosis and/or HCC in HBV patients in the Malaysian population.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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