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Anti-diabetic potential of Catharanthus roseus Linn. and its effect on the glucose transport gene (GLUT-2 and GLUT-4) in streptozotocin induced diabetic wistar rats

Al-Shaqha WM 1 , Khan M 2 , Salam N 1 , Azzi A 1 , Chaudhary AA 3

Affiliations 

  • 1 College of Medicine, Al-Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 13317-7544, Kingdom of Saudi Arabia (KSA)
  • 2 Department of Energy and Environmental sciences, Chaudhary Devi Lal University, Sirsa, Haryana, 125055, India
  • 3 College of Medicine, Al-Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 13317-7544, Kingdom of Saudi Arabia (KSA). anis.chaudhary@gmail.com
BMC Complement Altern Med, 2015;15:379.
PMID: 26490765 DOI: 10.1186/s12906-015-0899-6

Abstract

Catharanthus roseus is an important Ayurvedic medication in traditional medicine. It is potentially used in countries like India, South Africa, China and Malaysia for the healing of diabetes mellitus. Although, the molecular mechanisms behind this effect are yet to be exclusively explored. Due to the great antidiabetic and hyperlipidemic potential of c. roseus, we hypothesized that the insulin mimetic effect of ethanolic extract of c. roseus might add to glucose uptake through improvement in the expression of genes of the glucose transporter (GLUT) family messenger RNA (mRNA) in liver.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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