• 1 Department of Pharmacology, School of Medical Sciences, University Sains Malaysia, Kubang Kerian, Kelantan, Malaysia
Immunopharmacology, 1996 Jun;33(1-3):341-3.
PMID: 8856181 DOI: 10.1016/0162-3109(96)00104-x


This study examined the effects of streptozotocin-induced diabetes on blood pressure and cardiac tissue kallikrein levels in WKYR and SHR. Streptozotocin-induced diabetes caused significant (p < 0.001) increase in SBP and DBP in WKYR and SHR as compared with their respective controls. We also observed that the active cardiac tissue kallikrein levels reduced greatly (p < 0.001) in diabetic WKYR and SHR than the normal rats. These findings suggest for the first time that the cardiac tissue kallikrein formation may have a greater role in the regulation of blood pressure and cardiac function.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.