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Indication of acid suppression therapy and predictors for the prophylactic use of protonpump inhibitors vs. histamine-2 receptor antagonists in a Malaysian tertiary hospital

Oh AL 1 , Tan AG 2 , Phan HS 3 , Lee BC 4 , Jumaat N 5 , Chew SP 6 Show all authors , Wong SH 7 , Ting SH 8 , Subramaniam T 9

Affiliations 

  • 1 Department of Pharmacy, Sarawak General Hospital. Sarawak ( Malaysia ). ohailing79@yahoo.com
  • 2 Department of Pharmacy, Sarawak General Hospital. Sarawak ( Malaysia ). andrewgtan@gmail.com
  • 3 Department of Pharmacy, Sarawak General Hospital. Sarawak ( Malaysia ). hsphan@hotmail.com
  • 4 Department of Pharmacy, Sarawak General Hospital. Sarawak ( Malaysia ). baslee90@yahoo.com
  • 5 Department of Pharmacy, Sarawak General Hospital. Sarawak ( Malaysia ). nafisah.jumaat@gmail.com
  • 6 Department of Pharmacy, Sarawak General Hospital. Sarawak ( Malaysia ). ezvic2@hotmail.com
  • 7 Department of Pharmacy, Sarawak General Hospital. Sarawak ( Malaysia ). kaylawng@hotmail.com
  • 8 Department of Pharmacy, Sarawak General Hospital. Sarawak ( Malaysia ). tshui1025@gmail.com
  • 9 Department of Pharmacy, Sarawak General Hospital. Sarawak ( Malaysia ). jyshetha_87@yahoo.com
Pharm Pract (Granada), 2015 Apr-Jun;13(3):633.
PMID: 26445624 DOI: 10.18549/PharmPract.2015.03.633

Abstract

Proton-pump inhibitors (PPI) and histamine-2 receptor antagonists (H2RA) are common acid suppressants used in gastrointestinal disorders. The trend of usage in Malaysia has changed from predominantly H2RA to PPI from 2007 to 2008, 3.46 versus 2.87 and 2.99 versus 3.24 DDD (Defined Daily Dose)/1000 population/day respectively. This raises concerns as PPI overutilization amounts to higher cost expenditure and are associated with various untoward consequences such as Clostridium difficile-associated diarrhea, pneumonia, and osteoporosis.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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