Phylogenetic relationship of non-typeable Haemophilus influenzae isolated in Malaysia

Mohd-Zain Z 1 , Kamsani NH 2 , Ahmad N 3 , Clarke SC 4

Affiliations 

  • 1 Core of Health and Wellbeing, Universiti Teknologi MARA, Shah Alam, Selangor, Malaysia; Institute of Medical Molecular Biotechnology, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh, Selangor, Malaysia. Electronic address: zainimz@salam.uitm.edu.my
  • 2 Institute of Medical Molecular Biotechnology, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh, Selangor, Malaysia. Electronic address: mirakamsani@yahoo.com
  • 3 Institute for Medical Research, Kuala Lumpur, Malaysia. Electronic address: norazah@imr.gov.my
  • 4 Faculty of Medicine and Institute of Life Sciences, University of Southampton, UK; Southampton NIHR Respiratory Biomedical Research Unit, University Hospital Southampton Foundation NHS Trust, Southampton, UK; University of Southampton Malaysia Campus, Nusajaya, Johor, Malaysia. Electronic address: S.C.Clarke@soton.ac.uk
Infect Genet Evol, 2015 Dec;36:240-3.
PMID: 26394107 DOI: 10.1016/j.meegid.2015.09.017

Abstract

The epidemiology of non-typeable Haemophilus influenzae (NTHi) remains poorly understood. We therefore sought to determine the genetic relationship of 25 NTHi isolated from various states in Malaysia using multilocus sequence typing (MLST). The majority of isolates were obtained from sputum. There were 24 novel sequence types (STs). Eight isolates were single-locus variants, the remainder being singletons. Clustering was not based on clinical site of isolation or geographical origin. Despite the limited number of isolates examined in this study, we demonstrate that NTHi isolates in Malaysia are diverse and warrant further investigation.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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