Affiliations 

  • 1 Department of Biological and Biomedical Sciences, Aga Khan University, Pakistan
  • 2 Department of Biological Sciences, Faculty of Science and Technology, Sunway University, Malaysia. Electronic address: naveed5438@gmail.com
Microb Pathog, 2015 Nov;88:48-51.
PMID: 26276705 DOI: 10.1016/j.micpath.2015.08.005

Abstract

Granulomatous amoebic encephalitis due to Acanthamoeba is a chronic disease that almost always results in death. Hematogenous spread is a pre-requisite followed by amoebae invasion of the blood-brain barrier to enter the central nervous system. Given the systemic nature of this infection, a significant latent period of several months before the appearance of clinical manifestations is puzzling. Based on reported cases, here we propose pathogenetic mechanisms that explain the above described latency of the disease.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.