Affiliations 

  • 1 UCSI University, Kuala Lumpur, Malaysia. fazlollahk@yahoo.com
Int J Clin Pharm, 2015 Oct;37(5):675-7.
PMID: 26173939 DOI: 10.1007/s11096-015-0157-5

Abstract

Creatinine clearance estimation is widely used to evaluate the renal function of the patients in order to initiate or adjust the drugs dosage. However serum creatinine, as a muscle metabolism by-product, may not be a reliable parameter in underweight and/or non-ambulatory patients, such as geriatric, acquired immunodeficiency syndrome patients and bed-confined and cachexic cases. To avoid overestimation of the renal function in those patients, serum cystatin C can be considered as a sensitive and accurate alternative for serum creatinine.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.