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PGD: a pangolin genome hub for the research community

Tan TK 1 , Tan KY 2 , Hari R 1 , Mohamed Yusoff A 1 , Wong GJ 3 , Siow CC 3 Show all authors , Mutha NV 3 , Rayko M 4 , Komissarov A 4 , Dobrynin P 4 , Krasheninnikova K 4 , Tamazian G 4 , Paterson IC 5 , Warren WC 6 , Johnson WE 7 , O'Brien SJ 8 , Choo SW 9

Affiliations 

  • 1 Genome Informatics Research Laboratory, Centre for Research in Biotechnology for Agriculture (CEBAR), High Impact Research Building, University of Malaya, 50603 Kuala Lumpur, Malaysia Department of Oral and Craniofacial Sciences, Faculty of Dentistry, University of Malaya, 50603 Kuala Lumpur, Malaysia
  • 2 Genome Informatics Research Laboratory, Centre for Research in Biotechnology for Agriculture (CEBAR), High Impact Research Building, University of Malaya, 50603 Kuala Lumpur, Malaysia Institute of Biology Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur Malaysia
  • 3 Genome Informatics Research Laboratory, Centre for Research in Biotechnology for Agriculture (CEBAR), High Impact Research Building, University of Malaya, 50603 Kuala Lumpur, Malaysia
  • 4 Theodosius Dobzhansky Center for Genome Bioinformatics, Saint Petersburg State University, St. Petersburg 199004, Russia
  • 5 Department of Oral and Craniofacial Sciences, Faculty of Dentistry, University of Malaya, 50603 Kuala Lumpur, Malaysia Oral Cancer Research and Coordinating Centre, Faculty of Dentistry, University of Malaya, 50603 Kuala Lumpur, Malaysia
  • 6 McDonnell Genome Institute, Washington University, St Louis, MO 63108, USA
  • 7 Smithsonian Conservation Biology Institute, Front Royal, Virginia 22630, USA
  • 8 Theodosius Dobzhansky Center for Genome Bioinformatics, Saint Petersburg State University, St. Petersburg 199004, Russia Oceanographic Center, Nova Southeastern University, Ft Lauderdale, FL, 33004, USA
  • 9 Genome Informatics Research Laboratory, Centre for Research in Biotechnology for Agriculture (CEBAR), High Impact Research Building, University of Malaya, 50603 Kuala Lumpur, Malaysia Department of Oral and Craniofacial Sciences, Faculty of Dentistry, University of Malaya, 50603 Kuala Lumpur, Malaysia Genome Solutions Sdn Bhd, Suite 8, Innovation Incubator UM, Level 5, Research Management & Innovation Complex, University of Malaya, 50603 Kuala Lumpur, Malaysia l.choo@genomesolutions.com.my
Database (Oxford), 2016;2016.
PMID: 27616775 DOI: 10.1093/database/baw063

Abstract

Pangolins (order Pholidota) are the only mammals covered by scales. We have recently sequenced and analyzed the genomes of two critically endangered Asian pangolin species, namely the Malayan pangolin (Manis javanica) and the Chinese pangolin (Manis pentadactyla). These complete genome sequences will serve as reference sequences for future research to address issues of species conservation and to advance knowledge in mammalian biology and evolution. To further facilitate the global research effort in pangolin biology, we developed the Pangolin Genome Database (PGD), as a future hub for hosting pangolin genomic and transcriptomic data and annotations, and with useful analysis tools for the research community. Currently, the PGD provides the reference pangolin genome and transcriptome data, gene sequences and functional information, expressed transcripts, pseudogenes, genomic variations, organ-specific expression data and other useful annotations. We anticipate that the PGD will be an invaluable platform for researchers who are interested in pangolin and mammalian research. We will continue updating this hub by including more data, annotation and analysis tools particularly from our research consortium.Database URL: http://pangolin-genome.um.edu.my.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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