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Hydrogen Peroxide Scavenging Activity of Novel Coumarins Synthesized Using Different Approaches

Al-Amiery AA 1 , Al-Majedy YK 2 , Kadhum AA 2 , Mohamad AB 3

Affiliations 

  • 1 Department of Chemical and Process Engineering, University Kebangsaan Malaysia (UKM), Bangi, Selangor, 43000, Malaysia; Environmental Research Center, University of Technology (UOT), Baghdad, 10001, Iraq
  • 2 Environmental Research Center, University of Technology (UOT), Baghdad, 10001, Iraq
  • 3 Environmental Research Center, University of Technology (UOT), Baghdad, 10001, Iraq; Fuel Cell Institute, University Kebangsaan Malaysia (UKM), Bangi, Selangor, 43000, Malaysia
PLoS One, 2015;10(7):e0132175.
PMID: 26147722 DOI: 10.1371/journal.pone.0132175

Abstract

New derivatives of 7-hydroxy-4-methylcoumarin were synthesized using a chemical method and a microwave-assisted method to compare the feasibility, reaction times, and yields of the product. The newly synthesized coumarins were characterized by different spectroscopic techniques (FT-IR and NMR) and micro-elemental analysis (CHNS). In vitro antioxidant activities of these compounds were evaluated against hydrogen peroxide and were compared with standard natural antioxidant, vitamin C. Our results reveal that these compounds exhibit excellent radical scavenging activities.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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