CATH-Gene3D: Generation of the Resource and Its Use in Obtaining Structural and Functional Annotations for Protein Sequences

Dawson NL 1 , Sillitoe I 2 , Lees JG 2 , Lam SD 2 , Orengo CA 2

Affiliations 

  • 1 Institute of Structural and Molecular Biology, University College London, Gower Street, London, WC1E 6BT, UK. natalie.dawson.09@ucl.ac.uk
  • 2 Institute of Structural and Molecular Biology, University College London, Gower Street, London, WC1E 6BT, UK
Methods Mol Biol, 2017;1558:79-110.
PMID: 28150234 DOI: 10.1007/978-1-4939-6783-4_4

Abstract

This chapter describes the generation of the data in the CATH-Gene3D online resource and how it can be used to study protein domains and their evolutionary relationships. Methods will be presented for: comparing protein structures, recognizing homologs, predicting domain structures within protein sequences, and subclassifying superfamilies into functionally pure families, together with a guide on using the webpages.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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