Affiliations 

  • 1 a Department of Pharmaceutics , I.S.F. College of Pharmacy , Moga, Punjab , India
  • 2 b Department of Pharmacology , I.S.F. College of Pharmacy , Moga, Punjab , India
  • 3 c Brain Research Laboratory, Department of Pharmacology , Faculty of Pharmacy, Universiti Teknologi MARA (UiTM) , 42300, Puncak Alam, Malaysia
Artif Cells Nanomed Biotechnol, 2016 May;44(3):780-91.
PMID: 26107112 DOI: 10.3109/21691401.2015.1029622

Abstract

Clinically, the therapeutic outcomes in neurodegenerative disorders (NDs) by drug treatment are very limited, and the most insurmountable obstacle in the treatment of NDs is the blood-brain barrier (BBB), which provides the highest level of protection from xenobiotics. A great deal of attention still needs to be paid to overcome these barriers, and surface-engineered polymeric nanoparticles are emerging as innovative tools that are able to interact with the biological system at a molecular level for the desired response. The present review covers the potential importance of surface-structure-engineered nanoparticles to overcome the BBB for good bioavailability, and the evaluation of drug therapy in NDs.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.