Comparative performance of creatinine-based estimated glomerular filtration rate equations in the Malays: A pilot study in tertiary hospital in Malaysia

AIM: To validate the accuracy of estimated glomerular filtration rate (eGFR) equations in Malay population attending our hospital in comparison with radiolabeled measured GFR.
METHODS: A cross-sectional study recruiting volunteered patients in the outpatient setting. Chromium EDTA (51Cr-EDTA) was used as measured GFR. The predictive capabilities of Cockcroft-Gault equation corrected for body surface area (CGBSA), four-variable Modification of Diet in Renal Disease (4-MDRD), and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations were calculated.
RESULTS: A total of 51 subjects were recruited with mean measured GFR 42.04 (17.70-111.10) ml/min/1.73 m(2). Estimated GFR based on CGBSA, 4-MDRD, and CKD-EPI were 40.47 (16.52-115.52), 35.90 (14.00-98.00), and 37.24 (14.00-121.00), respectively. Higher accuracy was noted in 4-MDRD equations throughout all GFR groups except for subgroup of GFR ≥ 60 ml/min/1.73 m(2) where CGBSA was better.
CONCLUSIONS: The 4-MDRD equation seems to perform better in estimating GFR in Malay CKD patients generally and specifically in the subgroup of GFR < 60 ml/min/1.73 m(2) and both BMI subgroups.
Study site: University Malaya Medical Centre (UMMC), Kuala Lumpur, Malaysia