Affiliations 

  • 1 Department of Chemistry, Universiti Teknologi Malaysia, 81310 UTM Skudai, Johor, Darul Ta'zim, Malaysia; Department of Chemistry, Faculty of Science, University of Misan, Misan, Iraq
  • 2 Department of Chemistry, Government Degree College, Raiwind (Lahore), Pakistan
  • 3 Department of Chemistry, Faculty of Science, University of Misan, Misan, Iraq
  • 4 Department of Biomedical Engineering, Faculty of Engineering, Karabuk University, 78050 Karabuk, Turkey
  • 5 Department of Physics, COMSATS Institute of Information Technology, Islamabad, Pakistan. Electronic address: rafaqathussain@comsats.edu.pk
Mater Sci Eng C Mater Biol Appl, 2017 Nov 01;80:93-101.
PMID: 28866230 DOI: 10.1016/j.msec.2017.05.117

Abstract

Microwave assisted wet precipitation method was used to synthesize calcium deficient strontium doped β-tricalcium phosphate (Sr-βTCP) with a chemical formula of Ca2.96-xSrx(PO4)2. Sr-βTCP was reacted with monocalcium phosphate monohydrate [Ca(H2PO4)2.H2O, MCPM] in presence of water to furnish corresponding Sr containing brushite cement (Sr-Brc). The samples were characterized by using X-ray diffractometry (XRD), Fourier transform infrared spectroscopy (FTIR) and field emission scanning electron microscopy (FESEM). Strontium content in the prepared samples was determined by using inductively coupled plasma optical emission spectrometry (ICP-OES). The effect of Sr2+ions on the structural, mechanical, setting properties and drug release of the cement is reported. Incorporation of Sr2+ions improved the injectability, setting time and mechanical properties of the Brc. The release profiles of antibiotics incorporated in Brc and Sr-Brc confirmed that the Sr incorporation into the Brc results in the efficient release of the antibiotics from the cement.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.