α-glucosidase inhibitors isolated from Mimosa pudica L

Tasnuva ST 1 , Qamar UA 1 , Ghafoor K 2 , Sahena F 3 , Jahurul MHA 4 , Rukshana AH 5 Show all authors , Juliana MJ 1 , Al-Juhaimi FY 2 , Jalifah L 6 , Jalal KCA 3 , Ali ME 7 , Zaidul ISM 1

Affiliations 

  • 1 a Faculty of Pharmacy , International Islamic University Malaysia, Kuantan Campus , Kuantan , Malaysia
  • 2 b Department of Food Science and Nutrition , King Saud University , Riyadh , Saudi Arabia
  • 3 c Faculty of Science , International Islamic University Malaysia (IIUM), Kuantan Campus , Kuantan , Malaysia
  • 4 d Faculty of Food Science and Nutrition , Universiti Malaysia Sabah , Kota Kinabalu , Malaysia
  • 5 e Faculty of Basic Medical and Pharmaceutical Sciences , University of Science and Technology Chittagong , Chittagong , Bangladesh
  • 6 f Faculty of Science and Technology , University Kebangsaan Malaysia , Bangi , Malaysia
  • 7 g Nanotechnology and Catalysis Research Centre (NanoCat) , University of Malaya , Kuala Lumpur , Malaysia
Nat Prod Res, 2019 May;33(10):1495-1499.
PMID: 29281898 DOI: 10.1080/14786419.2017.1419224

Abstract

The aim of the study was to isolate digestive enzymes inhibitors from Mimosa pudica through a bioassay-guided fractionation approach. Repeated silica gel and sephadex LH 20 column chromatographies of bioactive fractions afforded stigmasterol, quercetin and avicularin as digestive enzymes inhibitors whose IC50 values as compared to acarbose (351.02 ± 1.46 μg mL-1) were found to be as 91.08 ± 1.54, 75.16 ± 0.92 and 481.7 ± 0.703 μg mL-1, respectively. In conclusion, M. pudica could be a good and safe source of digestive enzymes inhibitors for the management of diabetes in future.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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