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Raising concerns about the Sepsis-3 definitions

Sartelli M 1 , Kluger Y 2 , Ansaloni L 3 , Hardcastle TC 4 , Rello J 5 , Watkins RR 6 Show all authors , Bassetti M 7 , Giamarellou E 8 , Coccolini F 3 , Abu-Zidan FM 9 , Adesunkanmi AK 10 , Augustin G 11 , Baiocchi GL 12 , Bala M 13 , Baraket O 14 , Beltran MA 15 , Jusoh AC 16 , Demetrashvili Z 17 , De Simone B 18 , de Souza HP 19 , Cui Y 20 , Davies RJ 21 , Dhingra S 22 , Diaz JJ 23 , Di Saverio S 21 , Dogjani A 24 , Elmangory MM 25 , Enani MA 26 , Ferrada P 27 , Fraga GP 28 , Frattima S 29 , Ghnnam W 30 , Gomes CA 31 , Kanj SS 32 , Karamarkovic A 33 , Kenig J 34 , Khamis F 35 , Khokha V 36 , Koike K 37 , Kok KYY 38 , Isik A 39 , Labricciosa FM 40 , Latifi R 41 , Lee JG 42 , Litvin A 43 , Machain GM 44 , Manzano-Nunez R 45 , Major P 46 , Marwah S 47 , McFarlane M 48 , Memish ZA 49 , Mesina C 50 , Moore EE 51 , Moore FA 52 , Naidoo N 53 , Negoi I 54 , Ofori-Asenso R 55 , Olaoye I 56 , Ordoñez CA 57 , Ouadii M 58 , Paolillo C 59 , Picetti E 60 , Pintar T 61 , Ponce-de-Leon A 62 , Pupelis G 63 , Reis T 64 , Sakakushev B 65 , Kafil HS 66 , Sato N 67 , Shah JN 68 , Siribumrungwong B 69 , Talving P 70 , Tranà C 1 , Ulrych J 71 , Yuan KC 72 , Catena F 73

Affiliations 

  • 1 Department of Surgery, Macerata Hospital, Macerata, Italy
  • 2 2Department of General Surgery, Division of Surgery, Rambam Health Care Campus, Haifa, Israel
  • 3 3General Surgery Department, Bufalini Hospital, Cesena, Italy
  • 4 Trauma Service, Inkosi Albert Luthuli Central Hospital, Durban, South Africa
  • 5 5Department of Clinical Research & Innovation in Pneumonia and Sepsis, Vall d'Hebron Institute of Research (VHIR), Barcelona, Spain
  • 6 6Division of Infectious Diseases, Cleveland Clinic Akron General, Akron, OH USA
  • 7 8Infectious Diseases Division, Santa Maria Misericordia University Hospital, Udine, Italy
  • 8 96th Department of Internal Medicine, Hygeia General Hospital, Athens, Greece
  • 9 10Department of Surgery, College of Medicine and Health Sciences, UAE University, Al-Ain, United Arab Emirates
  • 10 11Department of Surgery, College of Health Sciences, Obafemi Awolowo University, Ile-Ife, Nigeria
  • 11 12Department of Surgery, University Hospital Centre, Zagreb, Croatia
  • 12 13Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy
  • 13 14Trauma and Acute Care Surgery Unit, Hadassah Hebrew University Medical Center, Jerusalem, Israel
  • 14 Department of Surgery, Bizerte Hospital, Bizerte, Tunisia
  • 15 Department of General Surgery, Hospital San Juan de Dios de La Serena, La Serena, Chile
  • 16 Department of General Surgery, Kuala Krai Hospital, Kelantan, Malaysia
  • 17 Department General Surgery, Kipshidze Central University Hospital, Tbilisi, Georgia
  • 18 19Department of Digestive Surgery, Cannes Hospital, Cannes, France
  • 19 20Department of Surgery, School of Medicine, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, Brazil
  • 20 21Department of Surgery, Tianjin Nankai Hospital, Nankai Clinical School of Medicine, Tianjin Medical University, Tianjin, China
  • 21 22Colorectal Unit, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
  • 22 23School of Pharmacy, Faculty of Medical Sciences, The University of the West Indies, St. Augustine, Eric Williams Medical Sciences Complex, Uriah Butler Highway, Champ Fleurs, Trinidad and Tobago
  • 23 24Division of Acute Care Surgery, Program in Trauma, R Adams Cowley Shock Trauma Center, University of Maryland, Baltimore, MD USA
  • 24 Department of Surgery, University Hospital of Trauma, Tirana, Albania
  • 25 26Sudan National Public Health Laboratory, Federal Ministry of Health, Khartoum, Sudan
  • 26 27Department of Medicine, Infectious Disease Division, King Fahad Medical City, Riyadh, Saudi Arabia
  • 27 28Department of Surgery, Virginia Commonwealth University, Richmond, VA USA
  • 28 29Division of Trauma Surgery, Department of Surgery, School of Medical Sciences, University of Campinas (Unicamp), Campinas, SP Brazil
  • 29 Istituto Clinico San Rocco di Franciacorta, Brescia, Italy
  • 30 31Department of General Surgery, Mansoura Faculty of Medicine, Mansoura University, Mansoura, Egypt
  • 31 Department of Surgery, Hospital Universitário Terezinha de Jesus, Faculdade de Ciências Médicas e da Saúde de Juiz de Fora, Juiz de Fora, Brazil
  • 32 33Division of Infectious Diseases, Department of Internal Medicine, American University of Beirut, Beirut, Lebanon
  • 33 34Clinic for Emergency Surgery, Medical Faculty, University of Belgrade, Belgrade, Serbia
  • 34 35Third Department of General Surgery, Jagiellonian University Medical College, Krakow, Poland
  • 35 36Department of Internal Medicine, Royal Hospital, Muscat, Oman
  • 36 Department of Emergency Surgery, City Hospital, Mozyr, Belarus
  • 37 38Department of Primary Care and Emergency Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
  • 38 Department of Surgery, The Brunei Cancer Centre, Jerudong Park, Jerudong, Brunei
  • 39 40Department of General Surgery, Faculty of Medicine, Erzincan University, Erzincan, Turkey
  • 40 Global Alliance for Infections in Surgery, Porto, Portugal
  • 41 42Department of Surgery, Division of Trauma, University of Arizona, Tucson, AZ USA
  • 42 43Department of Surgery, College of Medicine, Yonsei University, Seoul, South Korea
  • 43 44Surgical Disciplines, Immanuel Kant Baltic Federal University/Regional Clinical Hospital, Kaliningrad, Russian Federation
  • 44 45Department of Surgery, Universidad Nacional de Asuncion, Asuncion, Paraguay
  • 45 46Clinical Research Center, Fundacion Valle del Lili, Cali, Colombia
  • 46 472nd Department of General Surgery, Jagiellonian University Medical College, Krakow, Poland
  • 47 48Department of Surgery, Post-Graduate Institute of Medical Sciences, Rohtak, India
  • 48 49Department of Surgery, Radiology, University Hospital of the West Indies, Kingston, Jamaica
  • 49 50Infectious Diseases Division, Department of Medicine, Prince Mohamed Bin Abdulaziz Hospital, Ministry of Health, Riyadh, Saudi Arabia
  • 50 Second Surgical Clinic, Emergency Hospital of Craiova, Craiova, Romania
  • 51 52Department of Surgery, Denver Health Medical Center, University of Colorado, Denver, CO USA
  • 52 53Department of Surgery, Division of Acute Care Surgery, and Center for Sepsis and Critical Illness Research, College of Medicine, University of Florida, Gainesville, FL USA
  • 53 54Department of Surgery, University of KwaZulu-Natal, Durban, South Africa
  • 54 Department of Surgery, Emergency Hospital of Bucharest, Bucharest, Romania
  • 55 Research Unit, Health Policy Consult, Weija, Accra, Ghana
  • 56 57Department of Surgery, University of Ilorin, Teaching Hospital, Ilorin, Nigeria
  • 57 58Department of Surgery and Critical Care, Universidad del Valle, Fundación Valle del Lili, Cali, Colombia
  • 58 Department of Surgery, Hassan II University Hospital, Medical School of Fez, Sidi Mohamed Benabdellah University, Fez, Morocco
  • 59 60Department of Emergency Medicine, Santa Maria Misericordia University Hospital, Udine, Italy
  • 60 61Department of Anesthesia and Intensive Care, Azienda Ospedaliero-Universitaria Parma, Parma, Italy
  • 61 62Department of Surgery, UMC Ljubljana, Ljubljana, Slovenia
  • 62 63Laboratory of Clinical Microbiology, Department of Infectious Diseases, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
  • 63 64Department of General and Emergency Surgery, Riga East University Hospital "Gailezers", Riga, Latvia
  • 64 Emergency Post-Operative Department, Otavio De Freitas Hospital, Recife, Brazil
  • 65 General Surgery Department, Medical University, University Hospital St George, Plovdiv, Bulgaria
  • 66 67Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  • 67 68Department of Aeromedical Services for Emergency and Trauma Care, Graduate School of Medicine, Ehime University, Ehime, Japan
  • 68 69Department of Surgery, Patan Hospital, Patan Academy of Health Sciences Lalitpur, Kathmandu, Nepal
  • 69 70Department of Surgery, Faculty of Medicine, Thammasat University Hospital, Thammasat University, Rangsit, Pathum Thani Thailand
  • 70 Department of Surgery, North Estonia Medical Center, Tallinn, Estonia
  • 71 72First Department of Surgery, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic
  • 72 73Department of Emergency and Critical Care Medicine, Taipei Medical University Hospital, Taipei, Taiwan
  • 73 Department of Emergency Surgery, Parma Maggiore Hospital, Parma, Italy
World J Emerg Surg, 2018;13:6.
PMID: 29416555 DOI: 10.1186/s13017-018-0165-6

Abstract

The Global Alliance for Infections in Surgery appreciates the great effort of the task force who derived and validated the Sepsis-3 definitions and considers the new definitions an important step forward in the evolution of our understanding of sepsis. Nevertheless, more than a year after their publication, we have a few concerns regarding the use of the Sepsis-3 definitions.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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