The new complexes [CuL2
(H2
O)2
] and [FeL2
(CH3
O)2
] in which L =
β-mangostin were synthesised and characterised. The structure of the
ligand, β-mangostin was confirmed using NMR and the purity of ligand
was determined using HPLC. Both Cu(II) and Fe(II) complexes were
prepared by reaction between the ligand and the acetate of the metals in
one-step reaction. The synthesised compounds have been characterised
using UV-Visible, FTIR and CHNS analyser. Ligand and metal complexes
were tested against bacteria to assess on their antimicrobial properties using
Minimum Inhibitory Concentrations (MICs) and Minimum Bactericidal
Concentrations (MBCs) method. The elemental analysis and spectra data
suggested octahedral geometry for both Cu(II) and Fe(II) complexes. The
IR spectroscopy revealed that the chelation of Cu2+ and Fe2+ ion occurred
with hydroxyl and carbonyl group at C9
and C1 respectively of β-mangostin.
Both Cu(II) and Fe(II) complexes showed stronger inhibition against
Pseudomonas aeruginosa, Proteus vulgaris, Klebsiella pneumoniae and
Salmonella pneumonia at concentration 900 mg/mL and Escherichia coli
at 450 mg/mL compared to the ligand itself