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Which is the best method of sterilization for recycled bone autograft in limb salvage surgery: a radiological, biomechanical and histopathological study in rabbit

Yasin NF 1 , Ajit Singh V 2 , Saad M 3 , Omar E 4

Affiliations 

  • 1 Department of Orthopaedic Surgery, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh Campus, Selangor, Malaysia. drfaissal76@gmail.com
  • 2 Department of Orthopaedic Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. drvivek69@gmail.com
  • 3 Department of Oncology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. marniza@ummc.edu.my
  • 4 Department of Pathology, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh Campus, Selangor, Malaysia. effat@salam.uitm.edu.my
BMC Cancer, 2015;15:289.
PMID: 25884718 DOI: 10.1186/s12885-015-1234-9

Abstract

Limb salvage surgery is a treatment of choice for sarcomas of the extremities. One of the options in skeletal reconstruction after tumour resection is by using a recycled bone autograft. The present accepted methods of recycling bone autografts include autoclaving, pasteurization and irradiation. At the moment there is lack of studies that compare the effectiveness of various sterilization methods used for recycling bone autografts and their effects in terms of bone incorporation. This study was performed to determine the effects of different methods of sterilization on bone autografts in rabbit by radiological, biomechanical and histopathological evaluations.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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