A substantial percentage of patients will have an inadequate response to
clozapine in treatment resistance schizophrenia. Therefore, different
approaches need to be considered for managing this group of patients. We
present a case of a treatment resistant schizophrenia patient who shows poor
response toward clozapine. Later, he was started with haloperidol. Even
though antipsychotic superiority of clozapine in relation to haloperidol is
significant, this patient demonstrated otherwise.