• 1 Department of Plant Sciences, University of Cambridge, Cambridge, UK
  • 2 Biochemistry and Cell Biology, Rice University, Houston, TX, USA
  • 3 Bayer CropScience NV Innovation Center, Trait Discovery, Gent, Belgium
  • 4 School of Life Sciences, University of Warwick, Coventry, UK
  • 5 Department of Plant Sciences, University of Cambridge, Cambridge, UK.
Nat Plants, 2018 09;4(9):690-698.
PMID: 30127410 DOI: 10.1038/s41477-018-0224-8


In the last decade, the view of circadian oscillators has expanded from transcriptional feedback to incorporate post-transcriptional, post-translational, metabolic processes and ionic signalling. In plants and animals, there are circadian oscillations in the concentration of cytosolic free Ca2+ ([Ca2+]cyt), though their purpose has not been fully characterized. We investigated whether circadian oscillations of [Ca2+]cyt regulate the circadian oscillator of Arabidopsis thaliana. We report that in Arabidopsis, [Ca2+]cyt circadian oscillations can regulate circadian clock function through the Ca2+-dependent action of CALMODULIN-LIKE24 (CML24). Genetic analyses demonstrate a linkage between CML24 and the circadian oscillator, through pathways involving the circadian oscillator gene TIMING OF CAB2 EXPRESSION1 (TOC1).

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.