Affiliations 

  • 1 Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen DK-1958, Denmark; Faculty of Industrial Sciences & Technology, Universiti Malaysia Pahang, 26300 Gambang, Pahang, Malaysia. Electronic address: nazikussabah@ump.edu.my
  • 2 Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2100 Copenhagen, Denmark
  • 3 Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen DK-1958, Denmark
Food Chem, 2019 Jan 01;270:481-486.
PMID: 30174076 DOI: 10.1016/j.foodchem.2018.07.142

Abstract

A 5 mg/mL solution of water, methanol and acetone extracts of seaweeds were used for α-glucosidase inhibition assay hyphenated with high performance liquid chromatography-mass spectrometry (HPLC-HRMS). The results showed acetone extracts of Undaria pinnatifida has the strongest inhibitory effect against α-glucosidase activity with IC50 0.08 ± 0.002 mg/mL. The active compound found in Undaria pinnatifida was identified as fucoxanthin. Analytical standard sample of fucoxanthin significantly inhibited α-glucosidase with IC50 value 0.047 ± 0.001 mg/mL. An inhibition kinetics study indicates that fucoxanthin is showing mixed-type inhibition. These results suggest that Undaria pinnatifida has a potential to inhibit α-glucosidase and may be used as a bioactive food ingredient for glycaemic control.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.