Oxidative stress-induced alterations in seminal plasma antioxidants: Is there any association with keap1 gene methylation in human spermatozoa?

Darbandi M 1 , Darbandi S 1 , Agarwal A 2 , Baskaran S 2 , Sengupta P 3 , Dutta S 4 Show all authors , Mokarram P 5 , Saliminejad K 1 , Sadeghi MR 6

Affiliations 

  • 1 Department of Embryology and Andrology, Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran
  • 2 American Center for Reproductive Medicine, Cleveland Clinic, Cleveland, Ohio
  • 3 Department of Physiology, Faculty of Medicine, MAHSA University, Jenjarom, Malaysia
  • 4 Faculty of Dentistry, MAHSA University, Jenjarom, Malaysia
  • 5 Department of Biochemistry, Shiraz University of Medical Sciences, Shiraz, Iran
  • 6 Monoclonal Antibody Research Center, Avicenna Research Institute (ARI), ACECR, Tehran, Iran
Andrologia, 2019 Feb;51(1):e13159.
PMID: 30298637 DOI: 10.1111/and.13159

Abstract

Kelch-like ECH-associated protein 1 (keap1)-nuclear factor-erythroid 2-related factor 2 (Nrf2) pathway is one of the master regulators of cellular defence against oxidative stress. Epigenetic alterations like hypermethylation of keap1 gene impair keap1-Nrf2 system in several oxidative stress-associated diseases. The objective of this study was to evaluate the epigenetic status of keap1 in sperm DNA of normozoospermic subjects, having different levels of reactive oxygen species (ROS) in seminal plasma. Semen samples were obtained from 151 apparently healthy male partners of couples who attended the Avicenna infertility clinic. Samples were categorised into four groups according to their ROS levels: group A (n = 39, ROS 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

Similar publications