Reactive oxygen species-induced alterations in H19-Igf2 methylation patterns, seminal plasma metabolites, and semen quality

Darbandi M 1 , Darbandi S 1 , Agarwal A 2 , Baskaran S 2 , Dutta S 3 , Sengupta P 4 Show all authors , Khorram Khorshid HR 5 , Esteves S 6 , Gilany K 1 , Hedayati M 7 , Nobakht F 8 , Akhondi MM 9 , Lakpour N 1 , Sadeghi MR 10

Affiliations 

  • 1 Department of Embryology and Andrology, Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, 1936773493, Iran
  • 2 American Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, 44195, USA
  • 3 Faculty of Dentistry, MAHSA University, 42610, Selangor, Malaysia
  • 4 Department of Physiology, Faculty of Medicine, MAHSA University, 42610, Selangor, Malaysia
  • 5 Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, 1985713834, Iran
  • 6 ANDROFERT, Andrology and Human Reproduction Clinic, Campinas, 13075-460, Brazil
  • 7 Molecular Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University for Medical Sciences, Tehran, 1985717413, Iran
  • 8 Department of Basic Medical Sciences, Neyshabur University of Medical Sciences, Nishabur, 9314634814, Iran
  • 9 Monoclonal Antibody Research Center, Avicenna Research Institute (ARI), ACECR, Shahid Beheshti University, Evin, Tehran, 1936773493, Iran
  • 10 Monoclonal Antibody Research Center, Avicenna Research Institute (ARI), ACECR, Shahid Beheshti University, Evin, Tehran, 1936773493, Iran. Sadeghi@avicenna.ac.ir
J Assist Reprod Genet, 2019 Feb;36(2):241-253.
PMID: 30382470 DOI: 10.1007/s10815-018-1350-y

Abstract

PURPOSE: This study was conducted in order to investigate the effects of reactive oxygen species (ROS) levels on the seminal plasma (SP) metabolite milieu and sperm dysfunction.

METHODS: Semen specimens of 151 normozoospermic men were analyzed for ROS by chemiluminescence and classified according to seminal ROS levels [in relative light units (RLU)/s/106 sperm]: group 1 (n = 39): low (ROS 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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