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Increased DNA methylation of the SLC30A8 gene promoter is associated with type 2 diabetes in a Malay population

Seman NA 1 , Mohamud WN 2 , Östenson CG 3 , Brismar K 3 , Gu HF 3

Affiliations 

  • 1 Department of Molecular Medicine and Surgery, Rolf Luft Research Center for Diabetes and Endocrinology, M1:03 Karolinska University Hospital, Karolinska Institutet, Stockholm, Se-17176 Sweden ; Cardiovascular, Diabetes and Nutrition Research Centre, Institute for Medical Research, Kuala Lumpur, Malaysia
  • 2 Cardiovascular, Diabetes and Nutrition Research Centre, Institute for Medical Research, Kuala Lumpur, Malaysia
  • 3 Department of Molecular Medicine and Surgery, Rolf Luft Research Center for Diabetes and Endocrinology, M1:03 Karolinska University Hospital, Karolinska Institutet, Stockholm, Se-17176 Sweden
Clin Epigenetics, 2015;7:30.
PMID: 25793017 DOI: 10.1186/s13148-015-0049-5

Abstract

Recent studies have demonstrated that DNA polymorphisms in the solute carrier family 30 member 8 (SLC30A8) gene confer the risk susceptibility to type 2 diabetes (T2D). The present study aimed to analyze DNA methylation levels of this gene in T2D and diabetic nephropathy (DN).

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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