Genetic, epigenetic and protein analyses of intercellular adhesion molecule 1 in Malaysian subjects with type 2 diabetes and diabetic nephropathy

Abu Seman N 1 , Anderstam B 2 , Wan Mohamud WN 3 , Östenson CG 4 , Brismar K 4 , Gu HF 5

Affiliations 

  • 1 Rolf Luft Research Center for Diabetes and Endocrinology, Department of Molecular Medicine and Surgery, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden; Cardiovascular, Diabetes and Nutrition Research Centre, Institute for Medical Research, Kuala Lumpur, Malaysia
  • 2 Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska University Hospital, Huddinge, Karolinska Institutet, Stockholm, Sweden
  • 3 Cardiovascular, Diabetes and Nutrition Research Centre, Institute for Medical Research, Kuala Lumpur, Malaysia
  • 4 Rolf Luft Research Center for Diabetes and Endocrinology, Department of Molecular Medicine and Surgery, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden
  • 5 Rolf Luft Research Center for Diabetes and Endocrinology, Department of Molecular Medicine and Surgery, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden. Electronic address: Harvest.Gu@ki.se
J Diabetes Complications, 2015 Nov-Dec;29(8):1234-9.
PMID: 26255081 DOI: 10.1016/j.jdiacomp.2015.07.004

Abstract

Recent research has implicated that the inflammation may be a key pathophysiological mechanism in diabetic nephropathy (DN). Intercellular adhesion molecule 1 (ICAM-1) is an acute phase marker of inflammation. In the present study, we carried out genetic, epigenetic and protein analyses of ICAM-1 in a Malaysian population, including normal glucose tolerance (NGT) subjects and type 2 diabetes (T2D) patients with or without DN in order to evaluate its role in DN.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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