Lycopodium Alkaloids: Lycoplatyrine A, an Unusual Lycodine-Piperidine Adduct from Lycopodium platyrhizoma and the Absolute Configurations of Lycoplanine D and Lycogladine H

Yeap JS 1 , Lim KH 2 , Yong KT 3 , Lim SH 1 , Kam TS 1 , Low YY 1

Affiliations 

  • 1 Department of Chemistry, Faculty of Science , University of Malaya , 50603 Kuala Lumpur , Malaysia
  • 2 School of Pharmacy , University of Nottingham Malaysia Campus , Jalan Broga , 43500 Semenyih , Selangor , Malaysia
  • 3 Institute of Biological Sciences, Faculty of Science , University of Malaya , 50603 Kuala Lumpur , Malaysia
J Nat Prod, 2019 02 22;82(2):324-329.
PMID: 30698428 DOI: 10.1021/acs.jnatprod.8b00754

Abstract

Three new Lycopodium alkaloids comprising two lycodine-type alkaloids (1, 2) and one fawcettimine alkaloid (3), in addition to 16 known alkaloids, were isolated from Lycopodium platyrhizoma. The structures of these alkaloids were elucidated based on analysis of their NMR and MS data. Lycoplatyrine A (1) represents an unusual lycodine-piperidine adduct. The structures and absolute configurations of lycoplanine D (hydroxy-des- N-methyl-α-obscurine, 10) and lycogladine H (11) were confirmed by X-ray diffraction analysis.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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