Schwarzinicines A-G, 1,4-Diarylbutanoid-Phenethylamine Conjugates from the Leaves of Ficus schwarzii

Krishnan P 1 , Lee FK 1 , Yap VA 1 , Low YY 2 , Kam TS 2 , Yong KT 3 Show all authors , Ting KN 1 , Lim KH 1

Affiliations 

  • 1 School of Pharmacy , University of Nottingham Malaysia , Jalan Broga , 43500 Semenyih , Selangor , Malaysia
  • 2 Department of Chemistry, Faculty of Science , University of Malaya , 50603 Kuala Lumpur , Malaysia
  • 3 Institute of Biological Sciences, Faculty of Science , University of Malaya , 50603 Kuala Lumpur , Malaysia
J Nat Prod, 2020 01 24;83(1):152-158.
PMID: 31935094 DOI: 10.1021/acs.jnatprod.9b01160

Abstract

Schwarzinicines A-G (1-7), representing the first examples of 1,4-diarylbutanoid-phenethylamine conjugates, were isolated from the leaves of Ficus schwarzii. The structures of these compounds were determined by detailed analysis of their MS, 1D and 2D NMR data. Compounds 1-4 exhibited pronounced vasorelaxant effects in the rat isolated aorta (Emax 106-120%; EC50 0.96-2.10 μM). However, compounds 1 and 2 showed no cytotoxic effects against A549, MCF-7, and HCT 116 human cancer cells (IC50 > 10 μM).

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

MeSH terms
Similar publications