Hispidacine, an unusual 8,4'-oxyneolignan-alkaloid with vasorelaxant activity, and hispiloscine, an antiproliferative phenanthroindolizidine alkaloid, from Ficus hispida Linn

Yap VA 1 , Loong BJ 2 , Ting KN 2 , Loh SH 3 , Yong KT 4 , Low YY 5 Show all authors , Kam TS 5 , Lim KH 6

Affiliations 

  • 1 School of Pharmacy, University of Nottingham Malaysia Campus, Jalan Broga, 43500 Semenyih, Selangor, Malaysia
  • 2 Department of Biomedical Sciences, University of Nottingham Malaysia Campus, Jalan Broga, 43500 Semenyih, Selangor, Malaysia
  • 3 School of Biosciences, University of Nottingham Malaysia Campus, Jalan Broga, 43500 Semenyih, Selangor, Malaysia
  • 4 Institute of Biological Sciences, University of Malaya, 50603 Kuala Lumpur, Malaysia
  • 5 Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia
  • 6 School of Pharmacy, University of Nottingham Malaysia Campus, Jalan Broga, 43500 Semenyih, Selangor, Malaysia. Electronic address: KuanHon.Lim@nottingham.edu.my
Phytochemistry, 2015 Jan;109:96-102.
PMID: 25468714 DOI: 10.1016/j.phytochem.2014.10.032

Abstract

Hispidacine, an 8,4'-oxyneolignan featuring incorporation of an unusual 2-hydroxyethylamine moiety at C-7, and hispiloscine, a phenanthroindolizidine alkaloid, were isolated from the stem-bark and leaves of the Malaysian Ficus hispida Linn. Their structures were established by spectroscopic analysis. Hispidacine induced a moderate vasorelaxant activity in rat isolated aorta, while hispiloscine showed appreciable antiproliferative activities against MDA-MB-231, MCF-7, A549, HCT-116 and MRC-5 cell lines.

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