Macroline, akuammiline, sarpagine, and ajmaline alkaloids from Alstonia macrophylla

Lim SH 1 , Low YY 1 , Sinniah SK 2 , Yong KT 2 , Sim KS 2 , Kam TS 3

Affiliations 

  • 1 Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia
  • 2 Institute of Biological Sciences, University of Malaya, 50603 Kuala Lumpur, Malaysia
  • 3 Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia. Electronic address: tskam@um.edu.my
Phytochemistry, 2014 Feb;98:204-15.
PMID: 24342109 DOI: 10.1016/j.phytochem.2013.11.014

Abstract

A total of seventeen alkaloids, comprising six macroline (including alstofolinine A, a macroline indole incorporating a butyrolactone ring-E), two ajmaline, one sarpagine, and eight akuammiline alkaloids, were isolated from the stem-bark and leaf extracts of the Malayan Alstonia macrophylla. The structure and relative configurations of these alkaloids were established using NMR, MS and in several instances, confirmed by X-ray diffraction analysis. Six of these alkaloids were effective in reversing multidrug-resistance (MDR) in vincristine-resistant KB cells.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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